Frank has over 36 years of investing, management, sales & marketing experience in the MedTech space, the last 28 years as serial investor and entrepreneur. As an investor, he has funded over 40 MedTech companies. As an entrepreneur, he has founded, built, and exited several successful European MedTech distribution companies, including Regis Medical GmbH, Ovum Ventures GmbH (sold to Medtronic in 2009) and Cardiologic GmbH (sold to Boston Scientific in 2002). His companies have commercialized over 20 novel medical device technologies in Europe and helped establish new clinical standards of care, including cerebral embolic protection, transcatheter aortic valve replacement (TAVR), ultrasound renal denervation, and the world’s first pre-mounted coronary stents (Arterial Vascular Engineering). Following Boston Scientific’s acquisition of Cardiologic GmbH, Frank served as the General Manager of Boston Scientific’s Interventional Cardiology Division Germany. Previously, he held several management positions at St. Jude Medical (now part of Abbott), Inc., W. L. Gore & Associates, and AHSC American Hospital Supply Corp. (now part of Baxter).
David has over 34 years of experience in corporate management, audit and finance, the last 25 years in the MedTech sector. He is an experienced MedTech investor and entrepreneur. He has invested in over 20 MedTech companies and co-founded and managed several European MedTech distribution companies over the past 23 years, including Regis Medical GmbH, Ovum Ventures GmbH (sold to Medtronic 2009), and Cardiologic GmbH (sold to Boston Scientific in 2002). Following Boston Scientific’s acquisition of Cardiologic GmbH, he served as Finance Controller for Boston Scientific in Germany, Austria and Switzerland. Prior to joining Cardiologic GmbH as Co-General Manager in 1996, David was the CFO of Chiron Adatomed GmbH, a German subsidiary of Chiron Corporation (NASDAQ: CHIR). Prior to that, he worked in Ernst & Young’s Munich office, advising on corporate M&A transactions. David holds a degree in Accountancy from the University of Birmingham, UK and is a member of the Institute of Chartered Accountants in England & Wales (ACA, ICAEW).
Frederik has over eight years of experience in investment banking and portfolio management (both equity and debt). Prior to co-founding 415 CAPITAL, Frederik led new business development efforts at Regis Medical GmbH, where he sourced and evaluated new MedTech investment opportunities, leading the due diligence process for several early-stage MedTech deals. Prior to joining Regis Medical in 2016, Frederik worked in HSBC’s Leveraged & Acquisition Finance group in New York City where he structured leveraged loans and high-yield bonds for private equity-backed buyouts and corporate M&A transactions including several mid- and large-cap Healthcare deals. Previously, he was in charge of the day-to-day monitoring of HSBC’s US private equity-backed credit portfolio. Before moving to New York City, he was an Analyst at HSBC in London where he advised clients on cross-border M&A transactions and IPOs. Frederik holds an Hon. B.A. in Economics magna cum laude from the University of Toronto (University College), Canada.
With highly diverse backgrounds across engineering, management, and medicine, our Senior Venture Advisors are an invaluable asset in supporting deal flow, due diligence and oversight of the investment portfolio.
Mr. Braun is a distinguished MedTech engineer, inventor, and holder of several medical device patents. As 415 CAPITAL’s Chief Technology Advisor, Mr. Braun is intimately involved in the technical evaluation of new portfolio prospects. Mr. Braun ist the founder and CEO of Symedrix GmbH, a German manufacturer of specialty guidewires for minimally invasive cardiac procedures. Mr. Braun is a co-founder of CoRRect Medical, where he serves as CEO. Previously, Mr. Braun co-founded Reverse Medical Corp. and acted as R&D Director for the Neuroradiology product line prior to acquisition by Covidien in 2015 (now part of Medtronic). Mr. Braun also co-founded several successful MedTech distribution and consulting companies, providing clinical trial and regulatory support to dozens of MedTech startups. Previously, Mr. Braun held several roles at Medtronic, most recently as Clinical Specialist for the Endovascular Aneurysm Repair (EVAR) and Peripheral product lines. He started his engineering career in the R&D Department of Biomechanics & Prosthetics at Rüsch AG / Teleflex where he invented the Polyflex™ stent. Mr. Braun holds a B.Sc. in Biomedical Engineering from the University of Aachen, Germany.
Dr. Laborde is an internationally recognized Key Opinion Leader in interventional cardiology and one of the pioneers of transcatheter aortic valve replacement (TAVR). He currently serves as an advisor to several innovative medical device startups. Dr. Laborde was intimately involved in the technical and clinical development of the CardiAQ transcatheter mitral valve replacement (TMVR) system which was acquired by Edwards Life sciences in 2015, and previously the CoreValve transcatheter aortic valve replacement (TAVR) system which was acquired by Medtronic in 2009. Dr. Laborde also served as the Chief Medical Officer of CoreValve and has personally performed more CoreValve TAVR procedures than any other physician worldwide. He holds numerous patents for novel medical devices that have changed how cardiologists practice medicine and has designed new medical procedures to treat specific cardiac conditions. Dr. Laborde has trained hundreds of physicians internationally. Dr. Laborde previously served as the Co-Director of the Interventional Cardiology Department at Clinique Pasteur in Toulouse, France. He also held consulting positions at St. George Hospital in London, England; Glenfield Hospital in Leicester, England and the German Heart Center in Munich, Germany.
Mr. Michiels has over 30 years of experience in the MedTech space. He most recently served as the CEO of CardiAQ Valve Technologies, a venture funded start-up developing transcatheter mitral valve replacement (TMVR) technology which was acquired by Edwards Lifesciences in 2015. He previously served as COO of CoreValve which was acquired by Medtronic in 2009; and as President and COO of InterVentional Technologies (IVT) which was acquired by Boston Scientific in 2001. He helped drive both companies from cardiovascular start-ups to established market leaders. Mr. Michiels is currently a director of Aegis Surgical, Atrius, and FEops, all privately held companies developing novel cardiovascular technologies. Mr. Michiels is also a founding partner of CONSILIUM, a medical device market research company active in identifying, funding and greenhousing start-up technologies. Mr. Michiels holds a bachelor's degree in Economics from Antwerp University in Belgium and an MBA from the Kelley School of Business at Indiana University, Bloomington, Indiana, US.
Our Senior Clinical Advisors include some of the leading international voices in cardiovascular medicine. With a geographically diverse footprint, they are ideally positioned to support portfolio companies with valuable advice on their clinical strategies in Europe, North America, and Israel.
Prof. Fitzgerald is Professor of Medicine & Bioengineering at the Center for Cardiovascular Technology at Stanford University Medical School. Presently, Prof. Fitzgerald’s laboratory includes 17 postdoctoral fellows and graduate engineering students focused on state-of-the-art technologies in cardiovascular medicine. He has led or participated in over 175 clinical trials, published over 550 manuscripts / chapters, and lectures worldwide. He has trained over 150 post-docs in Engineering and Medicine in the past decade. In addition, he heads the Stanford / Asia MedTech innovation program. Prof. Fitzgerald has been principle / founder of twenty-one medical device companies in the San Francisco Bay Area. He has transitioned fourteen of these start-ups to large medical device companies. He serves on several boards of directors, advised dozens of medical device startups as well as multinational healthcare companies in the design and development of new diagnostic and therapeutic devices in the cardiovascular arena. In 2001, Prof. Fitzgerald was on the founding team of LVP Capital, a venture firm, focused on medical device and biotechnology start-ups in San Francisco. In 2009, he co-founded TriVentures in Israel, which is a venture fund focused on early-mid stage medical technology and digital healthcare.
Prof. Lange is the Medical Director and Director of the Cardiovascular Surgery Department at the German Heart Centre, Munich. Professor Lange previously held the role of Director of the Department of Heart and Vascular Surgery at the same institution from 1999. Through his career, Professor Lange’s research has focused on minimally invasive operation techniques, the reconstruction of heart valves and transcatheter procedures for valve implantation and reconstruction. Educated at the University of Bonn and the University of Munich, Professor Lange underwent a two-year training period at Harvard Medical School, Boston. Author of numerous scientific publications, Professor Lange was awarded an honorary degree by Capital Medical University, Beijing, China in 2006. He was also awarded the Forum Prize of the German Surgical Society in 1991 as well as the Ernst-Derra Prize (1993) and the Hancock Editions-Prize (1990) by the German Society of Thoracic, Cardiac and Vascular Surgery (GSTCVS). Professor Lange is an active member of the American Association for Thoracic Surgery (AATS), Cardiothoracic Surgery Network, European Association for Cardio-Thoracic Surgery (EACTS), GSTCVS and The Society of Thoracic Surgeons.
Prof. Piazza is Assistant Professor to the Cardiology Division at the McGill University Health Centre. Prof. Piazza earned his medical degree at McGill University, where he subsequently completed post-graduate training in Cardiology. He completed a one-year interventional Cardiology clinical fellowship at the Montreal Heart Institute and two subsequent fellowships – a two-year PhD research fellowship in transcatheter valve therapies at the Erasmus Medical Center in Rotterdam with Prof. Dr. Patrick Serruys, and a two-year clinical fellowship in the same domain at the German Heart Center, Munich with Prof. Dr. Rüdiger Lange. Prof. Dr. Piazza is cross-appointed between the McGill University Health Centre and the German Heart Centre in Munich. His clinical and research activities focus on valvular heart disease with focus on aortic and mitral valve therapies. Prof. Dr. Piazza holds directorship roles in several major Cardiology conferences including Trans- catheter Valve Therapeutics, PCR London Valves, PCR Asia/Chengdu Valves, and Heart Valve Society Meeting.
Prof. Schäfer is Chief Cardiologist at the Marienkrankenhaus in Hamburg, Germany. He previously served as the Director of Structural Heart Therapies and Innovations in Interventional Cardiology at the Department of Cardiology in Hamburg, Germany. Prof. Schäfer has more than 15 years of experience in the field of medical device therapy for structural heart disease. He is an internationally recognized Interventional Cardiologist and one of the leading physicians in transcatheter aortic valve placement (TAVR), transcatheter Mitral and tricuspid valve therapies (TMTT) and transcatheter therapies for heart failure (TTHF). Prof. Schäfer is a Key Opinion Leader in interventional Cardiology and has conducted multiple international workshops and courses, as well as more than 50 industry-driven multicenter trials as a principle site investigator. He is actively consulting multiple companies in designing new medical devices for treatment of structural heart disease and within this scope he supervised hundreds of transcatheter treatments around the world. Prof. Schäfer is a reviewer in several journals, has authored several chapters in books, and has published more than 150 articles in reputed international peer reviewed journals.